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Molecule

Pharmacist

Molecule · office · middle · full-time
aicryptotechweb3 formulationpharmaceutical sciencesGMPanalytical testingdocumentation
6.5
AI Score
The vacancy is well-defined but lacks compensation details, affecting overall quality.
no salary info
Job description
Molecule and BIO.xyz are building the foundation of Decentralized Science (DeSci) — where biotech meets web3 to make scientific research community-owned, transparent, and faster to market. Molecule provides the infrastructure to turn intellectual property (IP) into programmable, on-chain assets through our IP-NFT framework and evolving protocol stack. This enables researchers, patients, and communities to fund and govern biotech projects in new, open ways. [BIO.xyz](http://Bio.xyz) is the coordination and economic layer of DeSci, powering BioDAOs through funding, governance, and ecosystem alignment. Together, we are creating a new model for scientific discovery — one where breakthroughs are owned and advanced by the communities that believe in them.
Responsibilities
### What You'll Do - Design oral solid-dose formulations (capsules and tablets) from active properties up - excipient selection, diluents, binders, disintegrants, flow agents, and lubricants matched to each compound's solubility, stability, and dosing profile - Design sterile injectable formulations for our peptide pipeline - lyophile design, bulking agents, cryoprotectants, vial fill/finish at small scale, reconstitution protocols, and container-closure compatibility. Hands-on with EU GMP Annex 1 (sterile manufacturing) and applicable AMG/AMWHV requirements - Own encapsulation, blending, and aseptic processing end to end: powder characterization, blend uniformity, content uniformity, capsule fill weight control, scale-up from bench to production batches, and sterility assurance for the injectable side - Solve hard actives. Bromantane and modafinil bring oral-side challenges - low aqueous solubility, poor flow, dose accuracy at small fill weights. Peptides like BPC-157, GLP-1 analogs, and GHK-Cu bring injectable-side challenges - stability across the lyophile/reconstitution cycle, copper-complex integrity, peptide aggregation. You develop the techniques that make all of them reproducible - Build and run the analytical backbone: dissolution testing, assay/potency, content and weight uniformity, sterility (Ph. Eur. 2.6.1), endotoxin (Ph. Eur. 2.6.14), and stability programs (ICH Q1A - accelerated and long-term) to establish shelf life - Write documentation that holds up: master formulation records, batch records, specifications, and SOPs. Define what "in spec" means and enforce it. Clean data trails or it didn't happen - Partner with sourcing and QC on raw-material specs, incoming API characterization (identity, purity by HPLC, particle size), and supplier qualification. Build a qualified supplier network. Continuously improve - reduce variability, improve stability, lower cost-per-dose without compromising quality
Requirements
### Who You Are - **Defends decisions with data.** You'd rather run the test than guess. When asked why you chose X over Y, you have a data-grounded answer - **High bar on accuracy and sterility.** It's people's health. Dose accuracy, reproducibility, and sterility are non-negotiable - especially on injectables - **Expert in the room alone.** You work well as the sole expert on day one. No team around you for the first year, and that doesn't slow you down - **Engineers around complexity.** You see the regulatory complexity of the compound classes we work with clearly, and you engineer around it rather than pretending it isn't there ### Required - Approbation als Apotheker/in (German pharmacist license), or an EU-recognized pharmacy qualification with a clear path to German licensure. Alternatively: a degree in pharmaceutics, pharmaceutical sciences, or industrial pharmacy (MSc/PhD) with equivalent hands-on formulation depth - 5+ years of hands-on formulation experience in pharma, nutraceutical, compounding, or contract manufacturing - covering oral solid dose and at least one of: sterile injectables, topicals - Deep working knowledge of excipient functionality and compatibility, and of encapsulation/tableting unit operations - Practical command of dissolution, content uniformity, and stability study design and interpretation - Experience formulating poorly-soluble or low-dose actives - Working command of EU GMP (EudraLex Vol. 4), Annex 1 (sterile manufacturing), and the Apothekenbetriebsordnung (ApBetrO) or equivalent manufacturing-pharmacy framework - Rigor with documentation: batch records, specs, SOPs, and a clean data trail ### Strongly Preferred - Sterile injectable / lyophilization experience - peptide formulations specifically - Background in a German Herstellungsapotheke, hospital pharmacy compounding unit, or EU-licensed contract manufacturer - Experience formulating GLP-1 analogs (semaglutide, tirzepatide) or other peptide manufacturing under a quality-grade framework - Familiarity with cognitive/performance compounds, or with the broader peptide / longevity therapeutic landscape - Hands-on with HPLC, dissolution apparatus, particle sizing, Karl Fischer titration - Comfort owning scale-up from R&D batches to production - Working proficiency in German (regulatory and documentation context) and English (team working language)
Conditions
### What We Offer - A senior IC seat building the formulation function from scratch at a company at the intersection of biotech, blockchain, and AI - Pre-approved capex - you spec the equipment: lyophilizer, capsule filler, balance suite, HPLC, dissolution apparatus, Class II BSC - The team you need, once you've proven the foundation
About Molecule
Molecule is a decentralized biotech protocol building a web3 marketplace for research-related intellectual property (IP). It provides a scalable framework for biotech DAOs, connecting academics and biotech companies with funding while enabling communities to govern and own research IP.[1]
Web3, Biotech, DeSci · 50-200 · Houston, United States · Founded 2014 · https://www.molecule.xyz/?ref=sailonchain.com
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